Androstenedione → 9alpha-Hydroxyandrost-4-ene-3,17-dione

HRID 1381064

反応式

HRID 1381064 の反応式
[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH2:8][CH2:9][C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[CH:11]=4)[C@@H:6]1[CH2:5][CH2:4][C:3]2=[O:21].C[C@]12CC[C@H]3[C@@H](CCC4[C@]3(C)C=CC(=[O:41])C=4)[C@@H]1CCC2=O.C[C@]12CC=C3[C@@H](CCC4[C@]3(C)CCC(=O)C=4)[C@@H]1CCC2=O>>[OH:41][C@:17]12[CH2:18][CH2:19][C@@:2]3([CH3:1])[C@@H:6]([CH2:5][CH2:4][C:3]3=[O:21])[C@@H:7]1[CH2:8][CH2:9][C:10]1[C@:15]2([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[CH:11]=1

参加物

4

反応物 3

HCID 6128AndrostenedioneHCID 13472Androsta-1,4-diene-3,17-dioneHCID 2395959-Dehydroandrostenedione

生成物 1

HCID 104250179alpha-Hydroxyandrost-4-ene-3,17-dione

実験手順

We have carried on investigations with attention to the fact that corticoids can be prepared through fewer steps from the aforementioned androst-4-ene-3,17-dione, androsta-1,4-diene-3,17-dione or androsta-4,9(11) -diene-3,17-dione which has recently be produced inexpensively and in a large scale from 9α-hydroxy-androst-4ene-3,17-dione which has also recently be produced by a fermentative process.

出典と根拠

ORDレコード
ord-81cca16715ea4a11a038c0d52b078e49
出典データセット
uspto-grants-1986_04
特許番号
US04585591

関連ノート

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