Formic Acid → Methyl 5-formylpyrrole-3-carboxylate
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:10]#N)[NH:8][CH:9]=1)=[O:4].C(O)=[O:13]>[Ni]>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[O:13])[NH:8][CH:9]=1)=[O:4]参加物
4
実験手順
3.6 g (27 millimoles) of 2-cyanopyrrole-4-carboxylic acid methyl ester, 17 g of Raney nickel, and 450 ml of 75% formic acid are introduced, in a flask, into an oil bath preheated to 120° C. and made to react for one hour. Subsequently, the mixture is poured into 1 liter of ice water and repeatedly extracted with ether. After drying and concentration of the ether phase, 1.4 g (36% of theory) of 2-formylpyrrole-4-carboxylic acid methyl ester is obtained, mp 126° C.
後処理
- custompreheated to 120° C.
- customto react for one hour
- extractionrepeatedly extracted with ether
- customAfter drying
出典と根拠
- ORDレコード
- ord-60fdaed4569749c988842a25fa64e6e7
- 出典データセット
- uspto-grants-1986_04
- 特許番号
- US04585771
反応ノート
読み込み中…