Ethylenediamine → HCID 23323496、化合物

反応式

[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[C:14]#[N:15].[CH2:20](N)[CH2:21][NH2:22]>>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[C:14]1[NH:22][CH2:21][CH2:20][N:15]=1

参加物

反応物 2

HCID 3301Ethylenediamine

HCID 23323482HCID 23323482、化合物

生成物 1

HCID 23323496HCID 23323496、化合物収率 60%

実験手順

A mixture of 8.5 g (33 mmol) of 2-(2-fluoro-4-nitrophenylamino)-benzonitrile and 16.7 ml (249 mmol) of ethylenediamine was heated in an autoclave to 180° for 1 hour, and the reaction mixture was then worked up as described in Example (1a). After crystallisation from dichloromethane and ether/petroleum ether, the reaction product was obtained in a 60% yield.

後処理

temperaturewas heated in an autoclave to 180° for 1 hour
customAfter crystallisation from dichloromethane and ether/petroleum ether
customthe reaction product was obtained in a 60% yield

出典と根拠

ORDレコード: ord-abe0e78a1b9540648697eed08f137c60
出典データセット: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04585772

反応ノート

読み込み中…

参加物