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Phosgene → N-chloroformyl-3-(m-chloroanilino)propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 7-Chloro-2,3-dihydro-4-quinolone | HCID 88974 | — |
| 反応物 | 3-((3-Chlorophenyl)amino)propanoic acid | HCID 12470919 | — |
| 生成物 | N-chloroformyl-3-(m-chloroanilino)propionic acid | HCID 13457253 | — |
反応手順
A process of the preparation of 7-chloro-1,2,3,4-tetrahydro-4-quinolinone which comprises treating 3-(m-chloro-anilino)propionic acid with phosgene to produce N-chloroformyl-3-(m-chloroanilino)propionic acid, converting the said product, by the action of an organic base or by heating, into 3-(m-chlorophenyl)-2,6-dioxo-1,3-perhydrooxazine, and treating the latter with aluminium chloride in an inert organic solvent or with a strong acid, to provide 7-chloro-1,2,3,4-tetrahydro-4-quinolinone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04585867 |
| 出典データセット | uspto-grants-1986_04 |
| ORD ID | ord-747c8bb1ce0746fdad3b5d4d2ff2a4d4 |
| 出典メモ | uspto-grants-1986_04 |