1-Amino-2-propanol → beta-[(2-Hydroxypropyl)amino]-alpha-phenylbenzeneethanol

HRID 1381518

反応式

HRID 1381518 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([C@H:7]2[O:9][C@@H:8]2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:6]=1.[NH2:16][CH2:17][CH:18]([OH:20])[CH3:19]>CO.O>[OH:20][CH:18]([CH3:19])[CH2:17][NH:16][CH:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[CH:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:9]

参加物

5

反応物 2

HCID 41-Amino-2-propanolHCID 185583(R,R)-Stilbene oxide

生成物 1

HCID 14391208beta-[(2-Hydroxypropyl)amino]-alpha-phenylbenzeneethanol収率 84%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
125 °C

実験手順

A mixture of trans-stilbene oxide (3.93 g, 0.20 mole) and 1-amino-2-propanol (4.51 g, 0.060 mole) was heated in an oil bath at 125° C. for 1 hour. After standing at ambient temperature for 18 hours, the viscous oil was dissolved in 20 ml of methanol and diluted with water causing a white solid to precipitate. The solid was collected, washed with water, and dried under ambient conditions to give 4.57 g (84%) of the product which was recrystallized from toluene to give 3.65 g solids; m.p. 116°-118° C.

後処理

  1. customto precipitate
  2. customThe solid was collected
  3. washwashed with water
  4. customdried under ambient conditions

出典と根拠

ORDレコード
ord-9c7098268d474dcf98272a2f3eef5ded
出典データセット
uspto-grants-1989_02
特許番号
US04803200

関連ノート

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