Water → beta-[(2-Hydroxy-1-methylethyl)amino]-alpha-phenylbenzeneethanol

HRID 1381523

反応式

HRID 1381523 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([C@H:7]2[O:9][C@@H:8]2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:6]=1.[NH2:16][CH:17]([CH3:20])[CH2:18][OH:19].O>CO>[OH:19][CH2:18][CH:17]([NH:16][CH:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[CH:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:9])[CH3:20]

参加物

5

反応物 3

HCID 962WaterHCID 51262-AminopropanolHCID 185583(R,R)-Stilbene oxide

生成物 1

HCID 14391210beta-[(2-Hydroxy-1-methylethyl)amino]-alpha-phenylbenzeneethanol収率 79%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of trans-stilbene oxide (3.93 g, 0.020 mole) and 2-amino-1-propanol (4.51 g, 0.060 mole) was heated on a steam bath for 18 hours. The reaction mixture was dissolved in methanol (20 ml) and the solution poured into water (200 ml). The viscous oil which separated from the solution crystallized on standing. The solid was collected to obtain 4.29 g (79%) of material which was recrystallized from toluene to give 3.36 g of a white solid. The solid was dried in vacuo for 2 hours, m.p. 104°-105° C.

後処理

  1. temperaturewas heated on a steam bath for 18 hours
  2. customThe viscous oil which separated from the solution
  3. customcrystallized
  4. customThe solid was collected

出典と根拠

ORDレコード
ord-c0fab2521406409ca20e95d161d42351
出典データセット
uspto-grants-1989_02
特許番号
US04803200

関連ノート

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