Water → beta-[[3-(1-Methylethoxy)propyl]amino]-alpha-phenylbenzeneethanol

HRID 1381527ノート

反応式

HRID 1381527 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([C@H:7]2[O:9][C@@H:8]2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:6]=1.[CH:16]([O:19][CH2:20][CH2:21][CH2:22][NH2:23])([CH3:18])[CH3:17].O>CC(C)=O>[CH3:17][CH:16]([O:19][CH2:20][CH2:21][CH2:22][NH:23][CH:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[CH:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:9])[CH3:18]

参加物

5

反応物 3

HCID 962WaterHCID 761943-IsopropoxypropylamineHCID 185583(R,R)-Stilbene oxide

生成物 1

HCID 14391211beta-[[3-(1-Methylethoxy)propyl]amino]-alpha-phenylbenzeneethanol収率 66.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
140 °C

実験手順

A mixture of trans-stilbene oxide (1.96 g, 0.010 mole) and 3-isopropoxy-1-propylamine (3.51 g, 0.030 mole) was heated at 140° C. for 5 hrs. After standing at ambient temperature for 18 hrs the mixture was dissolved in acetone (20 ml) and the solution poured into water (120 ml). A solid formed rapidly and was collected by filtration and dried at ambient temperature. The solid (2.80 g, 89%) was recrystallized from toluene-isooctone to yield 2.08 g of a fluffy white solid, m.p. 106°-108° C.

後処理

  1. customA solid formed rapidly
  2. filtrationwas collected by filtration
  3. customdried at ambient temperature
  4. customThe solid (2.80 g, 89%) was recrystallized from toluene-isooctone

出典と根拠

ORDレコード
ord-75adb3ee7dff42f986f9648912ac5d8c
出典データセット
uspto-grants-1989_02
特許番号
US04803200

反応ノート

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