Pyridine N-Oxide → Ethyl 5-oxopentanoate

HRID 1381723

反応式

HRID 1381723 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].C(=O)(O)[O-:12].[Na+].[N+]1([O-])C=CC=CC=1>C1(C)C=CC=CC=1>[O:12]=[CH:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 3

HCID 12753Pyridine N-OxideHCID 84580Ethyl 5-bromovalerateHCID 516892Sodium Bicarbonate

生成物 1

HCID 11137279Ethyl 5-oxopentanoate収率 48.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 5-bromopentanoate (42 g), sodium bicarbonate (34 g) and pyridine N-oxide (38 g) in toluene (250 ml) are heated together under reflux in an atmosphere of nitrogen with vigorous stirring for 9 hours. After cooling, the product is partitioned with water (400 ml). The toluene layer is separated and the aqueous layer is extracted with a further amount of toluene (100 ml). The combined toluene extracts are dried over magnesium sulphate and the toluene removed by fractional distillation. The residue is distilled under vacuum to give ethyl 5-oxopentanoate as a colourless oil (14.1 g), m.s. M+ 144.

後処理

  1. temperatureunder reflux in an atmosphere of nitrogen
  2. temperatureAfter cooling
  3. customthe product is partitioned with water (400 ml)
  4. customThe toluene layer is separated
  5. extractionthe aqueous layer is extracted with a further amount of toluene (100 ml)
  6. dry with materialThe combined toluene extracts are dried over magnesium sulphate
  7. customthe toluene removed by fractional distillation
  8. distillationThe residue is distilled under vacuum

出典と根拠

ORDレコード
ord-7941e9fff64245f088b3da5d5a29cb3a
出典データセット
uspto-grants-1989_02
特許番号
US04803289

関連ノート

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