Methyl 4-(1H-imidazol-1-yl)benzoate → N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate

HRID 1381910

反応式

HRID 1381910 の反応式
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:6][CH:5]=1.[CH2:16]([N:23]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:24][CH2:25][NH2:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[OH2:2].[C:28]1([CH2:27][N:23]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1.[C:17]1([CH2:16][N:23]([CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

3

反応物 2

HCID 2766374Methyl 4-(1H-imidazol-1-yl)benzoateHCID 6394114N1,N1-Dibenzylethane-1,2-diamine

生成物 1

HCID 67833593N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate

実験手順

Heat 4.23 g (21.0 mmol) of 4-(1H-imidazol-1-yl)benzoic acid methyl ester and 5.00 g (21.0 mmol) of N,N-dibenzylethylenediamine in 10 mL of xylenes at reflux for about 48 hr. Cool the solution to room temperature. Filter to obtain crystals of the title compound.

後処理

  1. temperatureat reflux for about 48 hr
  2. filtrationFilter

出典と根拠

ORDレコード
ord-c768e08e13ee4479b9ccd4c63185e2fa
出典データセット
uspto-grants-1989_02
特許番号
US04804662

関連ノート

読み込み中…