Imidazole → Diethyl 3-(tert-Butyldimethylsilyloxy)glutarate

HRID 1381987

反応式

HRID 1381987 の反応式
N1C=CN=C1.[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].[OH:14][CH:15]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(Cl)Cl>[CH3:10][C:9]([Si:6]([CH3:8])([CH3:7])[O:14][CH:15]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])([CH3:12])[CH3:11]

参加物

5

反応物 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 96259Diethyl 3-hydroxyglutarate

生成物 1

HCID 13327289Diethyl 3-(tert-Butyldimethylsilyloxy)glutarate収率 102%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

To a solution of imidazole (40.85 g, 600 mmole) in dry CH2Cl2 (300 ml) was added dropwise a solution of t-butyldimethylsilyl chloride (45.2 g, 300 mmole) in dry CH2Cl2 (100 ml). After 15 minutes, the solution was treated dropwise over a 40 minute period with a solution of diethyl 3-hydroxyglutarate (40.8 g, 200 mmole) in CH2Cl2 (100 ml). After stirring at room temperature under argon for 18 hours, the mixture was washed with water and saturated NaCl solution, dried over Na2SO4 and evaporated. The crude product (73.04 g) was purified by chromatography on Merck silica gel (4000 ml), eluting with ethyl ether-hexane (1:9) to give title compound (~65 g, theory 63.6) as a colorless oil.

後処理

  1. washthe mixture was washed with water and saturated NaCl solution
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customThe crude product (73.04 g) was purified by chromatography on Merck silica gel (4000 ml)
  5. washeluting with ethyl ether-hexane (1:9)

出典と根拠

ORDレコード
ord-b41c852c814044aebc856d71768477a6
出典データセット
uspto-grants-1989_02
特許番号
US04804770

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