Potassium Carbonate → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

HRID 1381998

反応式

HRID 1381998 の反応式
Cl[C:2]1[C:24]([N+:25]([O-:27])=[O:26])=[C:23]([Cl:28])[C:22]([F:29])=[CH:21][C:3]=1[C:4]([C:6](=[CH:12][NH:13]CCC(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:28][C:23]1[C:24]([N+:25]([O-:27])=[O:26])=[C:2]2[C:3]([C:4]([OH:5])=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:12]=[N:13]2)=[CH:21][C:22]=1[F:29]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 178472018HCID 178472018、化合物

生成物 1

HCID 178469671Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

52 g of the product from Example 4 and 18.5 g of K2CO3 are heated at 140° C. for 4 hours in 160 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is isolated. It is dried and recrystallized from glycol methyl ether acetate. Yield: 35.8 g, melting point: 226°-8° C. (decomposes).

後処理

  1. additionThe mixture is subsequently poured onto ice
  2. customthe precipitated solid is isolated
  3. customIt is dried
  4. customrecrystallized from glycol methyl ether acetate

出典と根拠

ORDレコード
ord-f6a0323c7d3442f382cb357069b2dd59
出典データセット
uspto-grants-1989_02
特許番号
US04804760

関連ノート

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