Ethanol → 1-Benzyl-1-methyl-3-nitroguanidine

HRID 1382029ノート

反応式

HRID 1382029 の反応式
CNC[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:10][N:11](N=O)/[C:12](/[NH2:17])=[N:13]/[N+:14]([O-:16])=[O:15].[CH2:20](O)C>>[CH2:10]([N:11]([CH3:20])[C:12]([NH:13][N+:14]([O-:16])=[O:15])=[NH:17])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 702EthanolHCID 7669N-MethylbenzylamineHCID 95620601-Methyl-2-nitro-1-nitrosoguanidine

生成物 1

HCID 1356162101-Benzyl-1-methyl-3-nitroguanidine

実験手順

N-Methylbenzylamine (9.89 g, 0.082 mol) is added dropwise to a suspension of MNNG (10.0 g, 0.068 mol) in aqueous ethanol (1:1 ethanol:water, v/v) at 25° C. A gradual exotherm to 44° C. occurs over the next 15 minutes. After stirring for 42 hours at ambient temperature, the white slurry is filtered. The resultant white solid (7.13 g) is recrystallized from hexanes:ethanol to afford pure product (white crystals, 6.06 g, 43.0%, melting point 103° C.-107° C.).

後処理

  1. customto 44° C.
  2. customoccurs over the next 15 minutes
  3. filtrationthe white slurry is filtered
  4. customThe resultant white solid (7.13 g) is recrystallized from hexanes
  5. customethanol to afford pure product (white crystals, 6.06 g, 43.0%, melting point 103° C.-107° C.)

出典と根拠

ORDレコード
ord-b433fc0321064dea912f01027b16b4d7
出典データセット
uspto-grants-1989_02
特許番号
US04804780

反応ノート

読み込み中…