2-Bromopropanoyl chloride → HCID 15611036、化合物

HRID 1382159

反応式

HRID 1382159 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH2:14])(=[O:13])=[O:12].[Br:15][CH:16]([CH3:20])[C:17](Cl)=[O:18]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH:14][C:17](=[O:18])[CH:16]([Br:15])[CH3:20])(=[O:13])=[O:12]

参加物

3

反応物 2

HCID 979802-Bromopropanoyl chlorideHCID 209044Benzenesulfonamide, 2,5-dimethoxy-

生成物 1

HCID 15611036HCID 15611036、化合物

実験手順

A stirred mixture of 7.0 g (0.032 mole) of 2,5-dimethoxyphenylsulfonamide in 10 mL of 2-bromopropionyl chloride was heated at reflux for 40 minutes then allowed to cool to room temperature. The resultant solution was poured into petroleum ether. Crystals formed after scratching the sides of the flask and were collected by filtration. The filter cake was washed four times with fresh petroleum ether to yield 10.3 g of N-(2,5-dimethoxyphenylsulfonyl)-2-bromopropionamide (mp 116°-118° C.).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 40 minutes
  3. customCrystals formed
  4. filtrationwere collected by filtration
  5. washThe filter cake was washed four times with fresh petroleum ether

出典と根拠

ORDレコード
ord-5a22b3ebdf9b41f48650b929e3982123
出典データセット
uspto-grants-1989_02
特許番号
US04806145

関連ノート

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