Diphenyl Ether → 4(1H)-Quinolinone, 8-methoxy-3-(1-oxobutyl)-
反応式
[C:1]([C:6](=[CH:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])[C:7]([O:9]CC)=O)(=[O:5])[CH2:2][CH2:3][CH3:4].C1(OC2C=CC=CC=2)C=CC=CC=1>CCOCC>[C:1]([C:6]1[C:7](=[O:9])[C:19]2[C:14](=[C:15]([O:20][CH3:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]参加物
4
実験手順
Ethyl 2-butyryl-3-(2-methoxyphenylamino)acrylate (15.50 g, 0.053 mol) was added in portions to boiling diphenyl ether (400 ml) and the mixture heated under reflux for 1.5 hours. After cooling, the solution was diluted with ether and petroleum ether, filtered, and the solid washed with petroleum ether to give 3-butyryl-8-methoxy-4-(1H)-quinolone as light grey crystals (13.46 g, 63.1%, m.p. 200°-202°.
後処理
- temperaturethe mixture heated
- temperatureunder reflux for 1.5 hours
- temperatureAfter cooling
- filtrationfiltered
- washthe solid washed with petroleum ether
出典と根拠
- ORDレコード
- ord-e313ef4e13094df7acc22cc0919c20d8
- 出典データセット
- uspto-grants-1989_02
- 特許番号
- US04806550
反応ノート
読み込み中…