1,2,3,4-Tetrahydroisoquinoline → 1-(2-Chlorophenoxy)-4-(1,2,3,4-tetrahydroisoquinolyl)-2-butanol Hydrochloride Hydrate

HRID 1382393

反応式

HRID 1382393 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH:5](Cl)[CH:6]([OH:9])[CH2:7][CH3:8].[CH2:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][NH:16]1.O.Cl>C(O)CCC>[OH2:4].[ClH:1].[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH:6]([OH:9])[CH2:7][CH2:8][CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][NH:16]1

参加物

5

反応物 3

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 198402391-(o-Chlorophenoxy)-2-hydroxybutyl chlorideHCID 21885828Hydrate;hydrochloride

生成物 1

HCID 212745811-(2-Chlorophenoxy)-4-(1,2,3,4-tetrahydroisoquinolyl)-2-butanol Hydrochloride Hydrate

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 11.8 g. (0.05 mole) of 1-(2-chlorophenoxy)-2-hydroxybutyl chloride, 13.3 g. (0.1 mole) of 1,2,3,4-tetrahydroisoquinoline and 100 ml. of n-butanol was heated in a steel bomb at 120° C. for 24 hr. The reaction mixture was filtered at room temperature, the filtrate was mixed with 200 ml. 3N hydrochloric acid and extracted twice with 100 ml. isopropyl ether. The aqueous acidic solution was made basic and extracted with isopropyl ether and treated with ethereal hydrogen chloride. Recrystallization with isopropanol yielded 6 g. of the hydrochloride hydrate of the product which melted at 118°-120° C.

後処理

  1. additionA mixture of 11.8 g
  2. filtrationThe reaction mixture was filtered at room temperature
  3. additionthe filtrate was mixed with 200 ml
  4. extraction3N hydrochloric acid and extracted twice with 100 ml
  5. extractionextracted with isopropyl ether
  6. additiontreated with ethereal hydrogen chloride
  7. customRecrystallization with isopropanol
  8. customyielded 6 g

出典と根拠

ORDレコード
ord-9bfb7643045647b98f7ad1e1d668f317
出典データセット
uspto-grants-1989_02
特許番号
US04806555

関連ノート

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