Benzamide, N-cyano- → HCID 178512389、化合物

HRID 1382446

反応式

HRID 1382446 の反応式
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:4][CH2:3]1.[C:19]([NH:27][C:28]#[N:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[C:19]([NH:27][C:28]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:6][CH2:7]1)=[NH:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 84805Benzamide, N-cyano-HCID 111958234-Amino-1-(2-naphthyl)methylpiperidine

生成物 1

HCID 178512389HCID 178512389、化合物収率 40.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoyl cyanamide (0.67 g, 0.0042 m) in toluene (100 cm3) were refluxed for 15 hours. The solvent was evaporated and the residue recrystallised from the minimum amount of isopropyl alcohol and recrystallised twice more from ethanol to give 0.65 g of the title compound, m.p. dihydrochloride quarter hydrate, m.p. 260°-262° C.

後処理

  1. customThe solvent was evaporated
  2. customthe residue recrystallised from the minimum amount of isopropyl alcohol
  3. customrecrystallised twice more from ethanol

出典と根拠

ORDレコード
ord-8dae87f3430247cfba9c9f42b16f3681
出典データセット
uspto-grants-1989_02
特許番号
US04806552

関連ノート

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