Pinacolone → 1-Hydroxy-4,4-dimethylpent-1-en-3-one

HRID 1382484

反応式

HRID 1382484 の反応式
[CH3:1][C:2](=[O:7])[C:3]([CH3:6])([CH3:5])[CH3:4].[CH:8](OC)=[O:9]>C(OCC)C>[CH3:4][C:3]([CH3:6])([CH3:5])[C:2](=[O:7])[CH:1]=[CH:8][OH:9]

参加物

4

反応物 2

HCID 6416PinacoloneHCID 7865Methyl formate

生成物 1

HCID 405073641-Hydroxy-4,4-dimethylpent-1-en-3-one収率 97.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
30 °C

実験手順

56.0 g (0.5 mole) of potassium tert.-butylate are added to a mixture of 50.0 g (0.5 mole) of pinacolone and 42.0 g (0.5 mole) of methyl formate at 15° to 20° C., with cooling. The reaction mixture is subsequently stirred at 30° C. for 12 hours. For working up, 400 ml of diethyl ether are added and the product precipitated is filtered off with suction and dried. 62.3 g (75% of theory) of 4,4-dimethyl-1-hydroxy-1-penten-3-one, as the potassium salt, are obtained in the form of a light yellow powder.

後処理

  1. temperaturewith cooling
  2. customthe product precipitated
  3. filtrationis filtered off with suction
  4. customdried

出典と根拠

ORDレコード
ord-a52803208ca64874b92d541a6f8a99c0
出典データセット
uspto-grants-1989_02
特許番号
US04806644

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