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2,2,2-Trifluoroacetophenone → 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2,2-Trifluoroacetophenone | HCID 9905 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | (4-Fluorobenzyl)triphenylphosphonium chloride | HCID 2733554 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene | HCID 57056367 | 90% |
反応手順
2,2,2-Trifluoroacetophenone is reacted with triphenyl-(4-fluorobenzyl)-phosphonium chloride (R. A. Jones: Australian J. Chem. 18, 903-6 (1965) in ethanol in the presence of sodium ethoxide. 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene is obtained with a yield of 90%; b.p.: 105°-107° C./0.2 mm Hg, m.p.: 35°-41° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04806685 |
| 出典データセット | uspto-grants-1989_02 |
| ORD ID | ord-018a985c58db4b17bdd4b5052bf80006 |
| 出典メモ | uspto-grants-1989_02 |