Hydrochloric Acid → HCID 70377366、化合物
反応式
[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([O:24]COC)=[CH:20][CH:19]=2)[C:14]([F:17])([F:16])[F:15])=[CH:8][CH:7]=1.[ClH:35]>>[ClH:35].[CH3:34][N:2]([CH3:1])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[C:13]([C:18]2[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=2)[C:14]([F:16])([F:17])[F:15])=[CH:10][CH:11]=1参加物
3
実験手順
0.76 g (1.62 mmoles) of 1-[4-(2-dimethylamino-ethoxy)-phenyl]-1-phenyl-3,3,3-trifluoro-2-[4-(methoxy-methoxy)-phenyl]-propene are dissolved in 8 ml of a 1% methanolic hydrochloric acid. The solution is heated for 0.5 hour, then evaporated, and the product is crystallized from isopropanol. 0.56 g (74%) of the aimed compound is obtained; m.p.: 196°-220° C.
後処理
- temperatureThe solution is heated for 0.5 hour
- customevaporated
- customthe product is crystallized from isopropanol
出典と根拠
- ORDレコード