HCID 178440264、化合物 → 1h-Imidazole-5-carboxaldehyde, 4-propyl-

HRID 1382784ノート

反応式

HRID 1382784 の反応式
[CH2:1]([C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH2:9][OH:10])[CH2:2][CH3:3]>O1CCOCC1.[O-2].[Mn+4].[O-2]>[CH2:1]([C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH:9]=[O:10])[CH2:2][CH3:3]

参加物

4

反応物 1

HCID 178440264HCID 178440264、化合物

生成物 1

HCID 135486171h-Imidazole-5-carboxaldehyde, 4-propyl-収率 73.6%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 5-propyl-1H-imidazole-4-methanol (4.0 g) and manganese (IV) oxide (10.0 g) in 1,4-dioxan (150 ml) was heated at reflux under nitrogen for 1 h. The hot suspension was filtered (Hyflo), washed with hot 1,4-dioxan (100 ml) and evaporated to give the title compound (2.9 g) as a solid, m.p. 120°-124°.

後処理

  1. temperaturewas heated
  2. temperatureat reflux under nitrogen for 1 h
  3. filtrationThe hot suspension was filtered (Hyflo)
  4. washwashed with hot 1,4-dioxan (100 ml)
  5. customevaporated

出典と根拠

ORDレコード
ord-99de9a7c13e141b7a9764bad08659136
出典データセット
uspto-grants-1989_02
特許番号
US04808581

反応ノート

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