1-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one → 1-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)propan-1-one

HRID 1382841ノート

反応式

HRID 1382841 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH:9]=[CH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2>CO>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH2:9][CH2:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2

参加物

3

反応物 1

HCID 538459351-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one

生成物 1

HCID 137856631-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)propan-1-one収率 71%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 200 mg of the product of Step A in 10 ml of methanol was hydrogenated in the presence of palladized activated charcoal at room temperature until absorption ceased and was then filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica. Elution with a 6-3-1 cyclohexane-dichloromethane-triethylamine mixture yielded 143 mg of 1-(2-hydroxyphenyl)-3-(1H-indol-4-yl)-1-propanone melting at ≃143° C.

後処理

  1. customwas hydrogenated in the presence of palladized activated charcoal at room temperature until absorption
  2. filtrationwas then filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica
  5. washElution with a 6-3-1 cyclohexane-dichloromethane-triethylamine mixture

出典と根拠

ORDレコード
ord-97648cff80d94f8283056914e3f47957
出典データセット
uspto-grants-1989_02
特許番号
US04808609

反応ノート

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