Epichlorohydrin → HCID 57291601、化合物

HRID 1382842ノート

反応式

HRID 1382842 の反応式
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([CH:9]1[O:11][CH2:10]1)Cl.[OH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=[O:31])[CH:20]=[CH:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[CH:25][NH:26]2>CC(C)=O>[O:11]1[CH2:10][CH:9]1[CH2:7][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=[O:31])[CH:20]=[CH:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[CH:25][NH:26]2

参加物

5

反応物 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 538459351-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one

生成物 1

HCID 57291601HCID 57291601、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

First 3.46 g of potassium carbonate and then 10.5 ml of epichlorohydrin were added to a solution of 4 g of 1-[2-hydroxyphenyl]-3-(1H-indol-4-yl)-2-propen-1-one in 80 ml of acetone and the mixture was refluxed for 50 hours under an inert atmosphere and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica. Elution with a 95-5 dichloromethane-ethyl acetate mixture yielded 2.26 g of 1-[2-[(2-oxiranyl)-methoxy]-phenyl]-3-(1H-indol-4-yl)-2-propen-1-one.

後処理

  1. temperaturethe mixture was refluxed for 50 hours under an inert atmosphere
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica
  5. washElution with a 95-5 dichloromethane-ethyl acetate mixture

出典と根拠

ORDレコード
ord-ed79a7725fa1420984771c47c737d67f
出典データセット
uspto-grants-1989_02
特許番号
US04808609

反応ノート

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