Ammonia → Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-

HRID 1382866ノート

反応式

HRID 1382866 の反応式
C([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[CH:9]=[CH:10][N:11](C)[CH3:12])=O.N>C(O)C>[CH3:14][N:7]1[C:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:3]=2[C:4](=[O:17])[N:5]([CH3:16])[C:6]1=[O:15]

参加物

4

反応物 2

HCID 222AmmoniaHCID 54245828HCID 54245828、化合物

生成物 1

HCID 3086912Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-収率 84.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.47 g of 5-formyl-1,3-dimethyl-6-(2-dimethylaminovinyl)uracil was dissolved in ethanol, and ammonia was added thereto. The solution was stirred for 30 min at room temperature. The precipitated crystals were separated from the solution by filtration and recrystallized from ethanol to give 0.32 g of 1,3-dimethylpyrido[4,3-d]pyrimidine-2,4-dione (Compound 1).

後処理

  1. customThe precipitated crystals were separated from the solution by filtration
  2. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-aae985345d584ab5a9e0c8b770495557
出典データセット
uspto-grants-1989_02
特許番号
US04808618

反応ノート

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