Ammonium Hydroxide → Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 5-amino-1,3-dimethyl-

HRID 1382867ノート

反応式

HRID 1382867 の反応式
[C:1]([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[CH:9]=[CH:10][N:11](C)C)#[N:2].[NH4+].[OH-]>CN(C=O)C>[NH2:2][C:1]1[C:3]2[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=2[CH:9]=[CH:10][N:11]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 53675031HCID 53675031、化合物

生成物 1

HCID 3086910Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 5-amino-1,3-dimethyl-収率 70%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

1.0 g of 5-cyano-1,3-dimethyl-6-(2-dimethylaminovinyl)uracil and 5.0 ml of 30% ammonia aqueous solution were added to 22.5 ml of DMF. The solution was heated at 100° C. in a sealed tube for 24 hr. The precipitated crystals were separated by filtration, washed with ether and recrystallized from ethanol to give 0.61 g of 5-amino-1,3-dimethylpyrido[4,3-d]pyrimidine-2,4-dione (Compound 3).

後処理

  1. customThe precipitated crystals were separated by filtration
  2. washwashed with ether
  3. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-c2f3cd64f31e4fed83451ea6f0ef5b99
出典データセット
uspto-grants-1989_02
特許番号
US04808618

反応ノート

読み込み中…