Isovaleryl chloride → N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N,3-dimethylbutanamide

HRID 13829

反応式

HRID 13829 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:15][CH3:16])[C:12]([C:17]#[N:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1.C[Mg+].[Br-].[CH3:29][CH:30]([CH3:35])[CH2:31][C:32](Cl)=[O:33]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([N:15]([CH3:16])[C:32](=[O:33])[CH2:31][CH:30]([CH3:35])[CH3:29])[C:12]([C:17]#[N:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1

参加物

4

反応物 3

HCID 66054Isovaleryl chlorideHCID 687190456-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-2-(methylamino)pyridine-3-carbonitrileHCID 178418689HCID 178418689、化合物

生成物 1

HCID 68717246N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N,3-dimethylbutanamide

実験手順

The product of Step D Example 1 was reacted with MeMgBr followed by 3-methylbutanoyl chloride using the procedure of EXAMPLE 42 Step A to afford the title compound. HPLC/MS: 472.2 (M+1), 474.2 (M+3); Rt=4.43 min.

出典と根拠

ORDレコード
ord-f77414101d6f4d47b45db786e34fd591
出典データセット
uspto-grants-2010_06
特許番号
US07728141B2

関連ノート

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