Hydrogen Peroxide → HCID 14372165、化合物

HRID 1383009ノート

反応式

HRID 1383009 の反応式
[S:1]([C:5]1[O:13][C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].[OH:14]O.O>C(O)(=O)C>[S:1]([C:5]1[O:13][C:12]2[C:7](=[N+:8]([O-:14])[CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14372164Furo[3,2-b]pyridine-2-sulfonamide

生成物 1

HCID 14372165HCID 14372165、化合物収率 63.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

To a suspension of 2-sulfamoylfuro[3,2-b]pyridine (647 mg, 3.27 mmol) in glacial acetic acid (8 mL) was added 30% hydrogen peroxide (0.6 mL). This suspension was warmed at 60° C. for four hours to give a clear solution. Upon cooling the reaction mixture and adding water the product crystallized out. This pure product (444 mg, 63.5% yield) was collected by filtration, washed with water, ethanol and diethyl ether, mp: 236°-237° C. (decomposition).

後処理

  1. customto give a clear solution
  2. temperatureUpon cooling the reaction mixture
  3. customcrystallized out

出典と根拠

ORDレコード
ord-b71766f77c814328a55713543aafb0f8
出典データセット
uspto-grants-1989_02
特許番号
US04808595

反応ノート

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