Phenanthrene-9-carbaldehyde → 2-Ethoxymethyl-2-(((9-phenanthrenyl)methyl)amino)-1,3-propanediol hydrochloride

HRID 1383039

反応式

HRID 1383039 の反応式
[ClH:1].[CH:2]1[C:15]2[CH:14]=[C:13]([CH2:16][NH:17][C@@:18]([CH3:24])([C@@H:21]([OH:23])C)[CH2:19][OH:20])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.C1C2C=[C:36]([CH:39]=[O:40])C3C(=CC=CC=3)C=2C=CC=1.Cl.NC(COCC)(CO)CO>>[ClH:1].[CH2:39]([O:40][CH2:24][C:18]([NH:17][CH2:16][C:13]1[C:12]2[C:7]([C:6]3[CH:5]=[CH:4][CH:3]=[CH:2][C:15]=3[CH:14]=1)=[CH:8][CH:9]=[CH:10][CH:11]=2)([CH2:21][OH:23])[CH2:19][OH:20])[CH3:36]

参加物

4

反応物 3

HCID 78437Phenanthrene-9-carbaldehydeHCID 155993362-Amino-2-ethoxymethyl-1,3-propanediol hydrochlorideHCID 86741971(+-)(2R*,3S*)-2-((9-Phenanthrenylmethyl)amino)-2-methyl-1,3-butanediol hydrochloride

生成物 1

HCID 212736642-Ethoxymethyl-2-(((9-phenanthrenyl)methyl)amino)-1,3-propanediol hydrochloride

実験手順

Using the reductive amination procedure outlined for 7G, phenanthrene-9-carbaldehyde (Aldrich) and 2-amino-2-ethoxymethyl-1,3-propanediol hydrochloride.1/4H2O (8B) gave 2-ethoxymethyl-2-(((9-phenanthrenyl)methyl)amino)-1,3-propanediol hydrochloride mp 173°-175°, (EtOH/Et2O), (C, H, Cl, N).

出典と根拠

ORDレコード
ord-2d3f18eec6094fc68773a16b800e3f2b
出典データセット
uspto-grants-1989_02
特許番号
US04808625

関連ノート

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