化工社化工社 化学情報印刷レポート · 研究参考用
Propylamine → N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-propylpropionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propylamine | HCID 7852 | — |
| 反応物 | Propionyl chloride | HCID 62324 | — |
| 反応物 | 2-Chloro-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)nicotinonitrile | HCID 10150677 | — |
| 反応物 | 6-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-2-(propylamino)pyridine-3-carbonitrile | HCID 68718445 | — |
| 反応物 | HCID 178418689 | HCID 178418689 | — |
| 生成物 | N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-propylpropionamide | HCID 68718623 | — |
反応手順
6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-(propylamino)pyridine-3-carbonitrile (prepared by reaction of the product of Step C Example 1 with propylamine using the procedure of Step D EXAMPLE 26) was reacted with MeMgBr followed by propionyl chloride using the procedure of EXAMPLE 42 Step A to afford the title compound. HPLC/MS: 472.1 (M+1), 474.1 (M+3); Rt=4.40 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728141B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-343535a0b1044b68b862867a52f92f28 |
| 出典メモ | uspto-grants-2010_06 |