gamma-Cyclodextrine → Salbutamol

HRID 1383796

反応式

HRID 1383796 の反応式
[CH3:1][C:2]([NH:5][CH2:6][CH:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:4])[CH3:3].[O-]C(CCCCCCCCC)=O.C(O)[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)C(OC6[C@H](O)[C@@H](O)C(C7[C@H](O)[C@@H](O)C(O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]9[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]9CO)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO>O>[CH3:4][C:2]([NH:5][CH2:6][CH:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:1])[CH3:3]

参加物

4

反応物 2

HCID 44431027gamma-Cyclodextrine2 回HCID 86757112Salbutamol caprate2 回

生成物 1

HCID 2083Salbutamol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Salbutamol caprate and gamma-cyclodextrin were complexed by the kneading method. Salbutamol caprate (2.409 g) and gamma-cyclodextrin (7.591 g) were blended together. Water (12 mL) was added and the mixture ground together in a mortar with a pestle to form a uniform paste. Grinding was continued for 30 minutes. The paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours. The solid mass was broken up, passed through a 60 mesh screen and returned to the vacuum oven (40° C.; 0 bar) for 12 hours in order to ensure uniform drying of the complex. Analysis by HPLC for salbutamol base content, and Karl Fischer for moisture content gave the following results: % salbutamol base was 12.83%, and the moisture content was 7.92%. The complex was characterised by DSC, FT-IR and XRD. The solubility in aqueous solution was 3.2 mg/mL, and the pH of a saturated aqueous solution was 7.00.

後処理

  1. customthe mixture ground together in a mortar with a pestle to form a uniform paste
  2. customGrinding
  3. customThe paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours
  4. waitreturned to the vacuum oven (40° C.; 0 bar) for 12 hours in order
  5. customto ensure uniform drying of the complex

出典と根拠

ORDレコード
ord-d8062396edf646878c480b0348769b89
出典データセット
uspto-grants-2001_07
特許番号
US06255502B1

関連ノート

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