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Isobutylamine → 6-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutylamine | HCID 6558 | — |
| 反応物 | 2-Chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile | HCID 86610502 | — |
| 生成物 | 6-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile | HCID 68718043 | — |
反応手順
2-chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile (prepared from 6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-1,2-dihydro-2-oxopyridine-3-carbonitrile using conditions similar to Step C Example 1) was reacted with isobutylamine using the conditions of Step A EXAMPLE 27 to afford the title compound. HPLC/MS: 414.1 (M+1), 415.9 (M+3); Rt=4.68 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728141B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-fd748734de3948cba74050eaef402336 |
| 出典メモ | uspto-grants-2010_06 |