Acetic Anhydride → (6-Methylpyridin-2-yl)methyl acetate

HRID 1383825ノート

反応式

HRID 1383825 の反応式
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].[N+:8]1([O-])C(C)=[CH:10][CH:11]=[CH:12][C:13]=1[CH3:14]>>[C:5]([O:4][CH2:1][C:2]1[CH:10]=[CH:11][CH:12]=[C:13]([CH3:14])[N:8]=1)(=[O:7])[CH3:6]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 140832,6-Dimethylpyridine N-oxide

生成物 1

HCID 291137(6-Methylpyridin-2-yl)methyl acetate

反応条件

温度
110 °C

実験手順

Acetic anhydride (23 ml) was heated to 110° C. and 2,6-lutidine-N-oxide (20 g) was added dropwise over 1 hour. The solution was heated at 110° C. for five hours. After cooling, the crude mixture was distilled to yield 2-acetoxymethyl-6-methylpyridine (18.4 g, b.p. 110-120° C. @ 15 mmHg).

後処理

  1. temperatureAfter cooling
  2. distillationthe crude mixture was distilled

出典と根拠

ORDレコード
ord-9d21fda086014f35a60a392747967bee
出典データセット
uspto-grants-2001_07
特許番号
US06255305B1

反応ノート

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