3-Bromophenol → [2-(3-Bromophenoxy)ethyl]dimethylamine

HRID 1383926

反応式

HRID 1383926 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:10][N:11]([CH2:13][CH2:14]Cl)[CH3:12].CN(CCOC1C=CC(Br)=CC=1)C>>[CH3:10][N:11]([CH2:13][CH2:14][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:12]

参加物

4

反応物 3

HCID 115633-BromophenolHCID 213877(2-(4-Bromophenoxy)ethyl)dimethylamineHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

生成物 1

HCID 413371[2-(3-Bromophenoxy)ethyl]dimethylamine収率 74%

実験手順

3-Bromophenol (5.0 g, 28.9 mmol) and 2-(N, N-dimethylamino)ethyl chloride, hydrochloride (6.24 g, 43.3 mmol) were reacted by the general procedures as described in the preparation of N,N-dimethyl-2-(4-bromophenoxy)ethylamine. The residue was chromatographed on silica gel (dichloromethane/methanol 100:0 to 90:10) to give the title compound (5.2 g, 74%) as a pale yellow liquid.

後処理

  1. customThe residue was chromatographed on silica gel (dichloromethane/methanol 100:0 to 90:10)

出典と根拠

ORDレコード
ord-b8e9423d5e1542d4bee4f8582baa6077
出典データセット
uspto-grants-2001_07
特許番号
US06255496B1

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