2-(4-Chlorophenoxy)acetonitrile → HCID 178515906、化合物

HRID 1384002ノート

反応式

HRID 1384002 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][C:8]#[N:9])=[CH:4][CH:3]=1.C[O-].[Na+].Cl.Cl.[NH2:17][C:18]1[C:23](N)=[CH:22][CH:21]=[CH:20][C:19]=1[OH:25]>CO>[OH:25][C:19]1[C:18]2[NH:17][C:8]([CH2:7][O:6][C:5]3[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:9][C:23]=2[CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 3064442-(4-Chlorophenoxy)acetonitrileHCID 10942334Sodium MethoxideHCID 184017512,3-Diaminophenol--hydrogen chloride (1/2)

生成物 1

HCID 178515906HCID 178515906、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a 50 ml single neck round bottom flask, under a nitrogen atmosphere, 4-chlorophenoxyacetonitrile (0.46 g, 2.79 mmol) was admixed in methanol (11 ml). The contents were stirred to achieve dissolution. To this solution were added sodium methoxide (0.164 g, 3.0 mmol). The resulting mixture was stirred for about 40 minutes. To this mixture was added 2,3-diaminophenol dihydrochloride salt (0.5 g, 2.5 mmol) and the resulting mixture was stirred for two hours at room temperature. The reaction mixture was filtered and the filtrate was added to 60 ml of water. A light brown precipitate formed and this precipitate is removed by filtration, and washed with 20 ml of water. The solid was dried in a vacuum oven overnight.

後処理

  1. dissolutiondissolution
  2. stirringThe resulting mixture was stirred for about 40 minutes
  3. stirringthe resulting mixture was stirred for two hours at room temperature
  4. filtrationThe reaction mixture was filtered
  5. additionthe filtrate was added to 60 ml of water
  6. customA light brown precipitate formed
  7. customthis precipitate is removed by filtration
  8. washwashed with 20 ml of water
  9. customThe solid was dried in a vacuum oven overnight

出典と根拠

ORDレコード
ord-367561454c35434b852efeb8becfcc7b
出典データセット
uspto-grants-2001_07
特許番号
US06255494B1

反応ノート

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