3,4,5-Trimethoxybenzoic Acid → 2-Bromo-3,4,5-trimethoxybenzoic acid

HRID 1384050

反応式

HRID 1384050 の反応式
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9]>C(O)(=O)C>[Br:1][C:11]1[C:12]([O:16][CH3:17])=[C:13]([O:14][CH3:15])[C:5]([O:4][CH3:3])=[CH:6][C:7]=1[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 83573,4,5-Trimethoxybenzoic AcidHCID 24408Bromine

生成物 1

HCID 3130972-Bromo-3,4,5-trimethoxybenzoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of bromine (100 mmol) in 100 mL of acetic acid is added dropwise to a solution of 3,4,5-trimethoxybenzoic acid (100 mmol) in 100 mL of acetic acid cooled by an ice water bath. After the red color of the resulting mixture is discharged, the mixture is poured onto 500 g of crushed ice. The resulting solid is collected by filtration, dried over P2O5 in vacuo, and recrystallized from Et2O to give the product as a pale yellow solid.

後処理

  1. temperaturecooled by an ice water bath
  2. filtrationThe resulting solid is collected by filtration
  3. dry with materialdried over P2O5 in vacuo
  4. customrecrystallized from Et2O

出典と根拠

ORDレコード
ord-4251066a793447ee9e4d8ca065c1be2c
出典データセット
uspto-grants-2001_07
特許番号
US06258360B1

関連ノート

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