2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(4-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline hydrochloride
反応式
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[C:7]([Cl:9])=[O:8].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:6]3[S:5][CH:4]=[N:3][C:2]=3[CH3:1])=[O:8])[CH2:27][CH2:26]2)[N:12]=1参加物
3
実験手順
The title compound was prepared from 4-methylthiazole-5-carbonyl chloride (1.1 g.) and 4-amino-6,7-dimethyoxy-2-(1-piperazinyl)quinazoline (2.0 g.) following previously described procedures. The product had a m.p. of 293°-295° C. with decomposition.
出典と根拠
- ORDレコード
- ord-968eaa645ff1486faeac2debc96542e5
- 出典データセット
- uspto-grants-2001_07
- 特許番号
- US06262059B1
反応ノート
読み込み中…