Phenylboronic Acid → HCID 21183701、化合物

反応式

Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:16][CH3:17])=[N:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[C:18]1(B(O)O)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH:11]1([N:8]2[C:9]3[C:5](=[CH:4][CH:3]=[C:2]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:10]=3)[C:6]([CH2:16][CH3:17])=[N:7]2)[CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

反応物 2

HCID 66827Phenylboronic Acid

HCID 22733808HCID 22733808、化合物

生成物 1

HCID 21183701HCID 21183701、化合物収率 77.2%

実験手順

This compound was prepared according to the method of Example 55, using 128 mg (0.437 mmol, 1.0 equiv) 6-bromo-1-cyclopentyl-3-ethyl-1H-indazole and 75 mg (0.612 mmol, 1.4 equiv) phenyl boronic acid as starting materials, to give 98 mg (77%) of white crystals: mp 72-74° C.; Anal. calcd for C20H22N2: C, 82.77; H, 7.64; N, 9.65. Found: C, 81.95; H, 7.82; N, 9.75.

後処理

customThis compound was prepared

出典と根拠

ORDレコード: ord-63975a9f926146478db1f5d3c769fbbf
出典データセット: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06262040B1

反応ノート

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