Water → N-(4-aminophenyl)-2-hydroxybenzamide

HRID 1385158ノート

反応式

HRID 1385158 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1)(=O)C.C(=O)(O)[O-].[Na+].O.[Cl-].[Na+]>CO>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:11](=[O:20])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])=[CH:18][CH:17]=1

参加物

6

反応物 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 18543278HCID 18543278、化合物

生成物 1

HCID 2781453N-(4-aminophenyl)-2-hydroxybenzamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 2-(4-aminophenylcarbamoyl)phenyl acetate (580 mg) in methanol (10 mL) is added saturated sodium bicarbonate (2 mL) and water (3 mL). The mixture is heated at 80° C. for 30 minutes, then poured into half-saturated aqueous sodium chloride and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate solution is dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto give an oil which
  5. customis then triturated with diethyl ether

出典と根拠

ORDレコード
ord-f114876feee048db8c9a97646038b614
出典データセット
uspto-grants-2001_07
特許番号
US06262082B1

反応ノート

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