化工社化工社 化学情報印刷レポート · 研究参考用
Benzene, 1-isocyanato-2-methoxy- → CXCR2 antagonist 8
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 反応物 | 2-Amino-5-Nitrophenol | HCID 4984721 | — |
| 生成物 | CXCR2 antagonist 8 | HCID 9796445 | 27% |
反応手順
N-(2-Hydroxy-4-nitrophenyl)-N′-(2-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 2-methoxy phenyl isocyanate (1 mmol.) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (82 mg, 27%). EI-MS m/z 302 (M−H)−
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06262113B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-2ddabcb6303c49b89aff50ab6d7d7887 |
| 出典メモ | uspto-grants-2001_07 |