4-Toluenesulfonyl chloride → N,N'-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane propane

関与物質

役割	名称	HCID	仕込み量
反応物	4-Toluenesulfonyl chloride	HCID 7397	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	1,3-Diiodopropane	HCID 12314	—
反応物	1,4,7-Triazacyclononane	HCID 188318	—
反応物	4,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononane	HCID 10906262	—
溶媒	Acetonitrile	HCID 6342	—
生成物	N,N'-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane propane	HCID 17939386	—

反応手順

1.1.19 1,3-Bis (1,4,7-triazacyclononane) propane N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) was prepared by reacting (1.1.3) with two equivalents of p-toluenesulfonyl chloride. Two equivalents of N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) hydrobromide were reacted with one equivalent of 1,3-diiodopropane in acetonitrile with excess potassium carbonate. 1,3-Bis[N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane propane (1.1.21) was isolated and purified by chromatography. The p-toluenesulfonyl groups were removed using sulfuric acid and HBr to yield the title compound (1.1.19).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06264966B1
出典データセット	uspto-grants-2001_07
ORD ID	ord-781102ef31f643c1bec493a801fd2e31
出典メモ	uspto-grants-2001_07