Sodium Cyanide → tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate
反応式
CS(O[C@:6]1([CH3:18])[CH2:10][CH2:9][CH2:8][N:7]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])(=O)=O.[C-:19]#[N:20].[Na+]>CN(C=O)C>[C:19]([CH2:18][C@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])#[N:20]参加物
4
反応条件
- 温度
- 60 °C
実験手順
To a solution of (R)-2-methanesulfonyloxy-methyl-pyrrolidine-1-carboxylic acid, tert-butyl ester (D3) (90 g, 0.32 mol) in DMF (1200 ml) was added sodium cyanide (24 g, 0.49 mol). Heated to 60° C. overnight. Reaction mixture was concentrated and partitioned between water and ether. The organic phase was dried and concentrated to give the title compound (18 g, 30%) (M-Boc) 110.
後処理
- customReaction mixture
- concentrationwas concentrated
- custompartitioned between water and ether
- customThe organic phase was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e9d3ce2b88874421a88b078b734a74b2
- 出典データセット
- uspto-grants-2001_07
- 特許番号
- US06265408B1
反応ノート
読み込み中…