Water → HCID 2794448、化合物

HRID 1386240ノート

反応式

HRID 1386240 の反応式
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

参加物

6

反応物 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

生成物 1

HCID 2794448HCID 2794448、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
125 °C

実験手順

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added. The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

後処理

  1. additionwas added
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

出典と根拠

ORDレコード
ord-7849328713464663824cc3bc1850ea67
出典データセット
uspto-grants-2001_07
特許番号
US06265421B1

反応ノート

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