Hydrochloric Acid → Benzoate hydrochloride

HRID 1386623ノート

反応式

HRID 1386623 の反応式
BrCCCCCCCCOC1C=CC([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=CC=1.O.C(OCC)(=O)C.[ClH:33]>CC1OC(C)CNC1>[ClH:33].[C:21]([OH:23])(=[O:22])[C:20]1[CH:24]=[CH:25][CH:17]=[CH:18][CH:19]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 8857Ethyl AcetateHCID 211822604-[4-(8-Bromooctyloxy)phenyl]benzoic acid

生成物 1

HCID 57447319Benzoate hydrochloride

試薬・触媒・溶媒 1

HCID 1108622,6-Dimethylmorpholine溶媒

実験手順

A suspension of 4-[4-(8-bromooctyloxy)phenyl]benzoic acid (1 g) in 2,6-dimethylmorpholine (3.06 ml) was refluxed for 30 minutes. The reaction mixture was added to mixture of water and ethyl acetate and adjusted to pH 2.0 with conc. HCl. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-[8-2,6-dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride (0.95 g).

後処理

  1. temperaturewas refluxed for 30 minutes
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-0c47cfe300914c43b9fd4ae074fea63e
出典データセット
uspto-grants-2001_07
特許番号
US06265536B1

反応ノート

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