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Sodium Iodide → 8-Iodo-1-octyne
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Oct-7-yn-1-yl 4-methylbenzene-1-sulfonate | HCID 10779145 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 8-Iodo-1-octyne | HCID 22621556 | 94.2% |
反応手順
A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06265569B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-31fa64294bc44b35b52744d807888dcc |
| 出典メモ | uspto-grants-2001_07 |