1-t-Butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl) piperidine → 4-(3-(3,5-Difluorophenyl)propyl)piperidine

HRID 1386745ノート

反応式

HRID 1386745 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[F:24][C:19]1[CH:18]=[C:17]([CH2:16][CH2:15][CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:22]=[C:21]([F:23])[CH:20]=1

参加物

4

反応物 1

HCID 211806591-t-Butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl) piperidine

生成物 1

HCID 211806144-(3-(3,5-Difluorophenyl)propyl)piperidine収率 70%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of 1-t-butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl)piperidine (from EXAMPLE 95, Step D) in 2.0 N HCl in MeOH was stirred at rt for 20 h. The solution was concentrated. Ether was added and the mixture was concentrated to remove excess HCl to afford 381 mg (70% yield from EXAMPLE 95, Step C) of the title compound: 1H NMR (500 MHz, CD3OD) δ 1.32-1.37 (4H), 1.64-1.68 (1H), 1.94 (d, J=14.2, 2H), 2.64 (t, J=7.3, 2H), 2.95 (t, J=13.1, 2H), 3 35 (d, J=12.6, 2H), 6.69-6.78 (m, 1H). 6.80 (d, J=8.2, 2H).

後処理

  1. concentrationThe solution was concentrated
  2. additionEther was added
  3. concentrationthe mixture was concentrated
  4. customto remove excess HCl

出典と根拠

ORDレコード
ord-89c15acd128948e7b09d01d3211c065b
出典データセット
uspto-grants-2001_07
特許番号
US06265434B1

反応ノート

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