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Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-[3-(4-Fluorophenyl)propyl]piperidin-4-ol | HCID 18364876 | — |
| 反応物 | 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester | HCID 59924617 | — |
| 生成物 | 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid | HCID 20672373 | — |
反応手順
The title compound was prepared from 2-(R)-(3-(R)-Formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) and 4-hydroxy-4-(3-(4-fluorophenyl)propyl) piperidine.HCl (from EXAMPLE 110, Step A) using procedures analogous to those described in EXAMPLE 1, Steps J and K. For the title compound: ESI-MS 537 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06265434B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-7b91175471fc491080b14c28e972e1a3 |
| 出典メモ | uspto-grants-2001_07 |