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Potassium Carbonate → 5-Methylisoxazole-4-carboxylic acid (4-(3-iodopropoxy)phenyl)amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,3-Diiodopropane | HCID 12314 | — |
| 反応物 | N-(4-Hydroxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide | HCID 19439747 | — |
| 生成物 | 5-Methylisoxazole-4-carboxylic acid (4-(3-iodopropoxy)phenyl)amide | HCID 53804942 | — |
反応手順
6.5 g (0.03 mol) of 5-methylisoxazole-4-carboxylic acid (4-hydroxyphenyl)amide are dissolved in 57 ml (0.5 mol) of 1,3-diiodopropane and 26.2 g (0.19 mol) of finely ground potassium carbonate are added with intensive stirring. The reaction is complete after approximately 4 h. Working up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid. The yield of the process was 6.7 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06265588B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-5e2b4484594241b88abc525754992300 |
| 出典メモ | uspto-grants-2001_07 |