Hydrochloric Acid → 2-Fluorobenzamidine hydrochloride

To a solution of lithium-bis(trimethylsilyl)amide (10 g, 59.8 mmol) in ether (200 ml) in a flame-dried flask, was added 2-fluorobenzonitrile (7.26 g, 59.8 mmol) dropwise over 45 min. at r.t. The mixture was stirred for a further 4 h. at r.t. then cooled to −10° C. and 6N HCl in ethanol (40 ml) added dropwise over 30 min. (exothermic). After allowing the reaction mixture to warm to r.t. overnight the precipitate was filtered and washed with ether then dried under high vacuum at 40° C. overnight. To remove LiCl the dried solid was re-suspended in ethanol (200 ml) and filtered, then the volume reduce volume to ca. 30 ml. The solution was filtered then triturated with ether, and stirred 30 min. at 4° C. Filtration of the precipitate, washing with ether and high vacuum drying overnight at 40° C., afforded the title compound (7.8 g, 44.7 mmol, 75% yield) as a white solid. MS: m/e=138 (M+).

1. temperaturethen cooled to −10° C.
2. temperatureto warm to r.t. overnight the precipitate
3. filtrationwas filtered
4. washwashed with ether
5. customthen dried under high vacuum at 40° C. overnight
6. customTo remove LiCl the dried solid
7. filtrationfiltered
8. filtrationThe solution was filtered
9. customthen triturated with ether
10. stirringstirred 30 min. at 4° C
11. filtrationFiltration of the precipitate
12. washwashing with ether and high vacuum
13. customdrying overnight at 40° C.

ORDレコード

ord-016f966e33414faab230bc32cc473179

出典データセット

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06265426B1