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Methanol → 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Benzo(B)Thiophene-2-Boronic Acid | HCID 2359 | — |
| 反応物 | 5-Bromo-2-(2-(pyrrolidin-1-yl)ethoxy)pyridine | HCID 10588166 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether | HCID 21182907 | 68% |
反応手順
By essentially following the procedure detailed in Example 1, Part B, the title compound was prepared from benzo[b]thiophene-2-boronic acid and 5-bromopyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether (Part A) in 68% yield as an oil following flash chromatography (SiO2; gradient of 0-4% MeOH in CHCl3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06265575B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-2e3a2f64e70b454b8abeeccb29a3e1e6 |
| 出典メモ | uspto-grants-2001_07 |