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Methanol → 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| 反応物 | 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether | HCID 21182907 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate | HCID 86757082 | 30% |
反応手順
By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 5-(benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether (Part B) and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 30% yield as a solid following flash chromatography (SiO2; 5% MeOH in CHCl3) The free base was converted to the dioxalate salt according to the conditions outlined in Example 1, Part C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06265575B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-f7c6834203724248a5c0b690a468b0dc |
| 出典メモ | uspto-grants-2001_07 |