6-Benzyloxy-2-dimethylaminobenzo[b]thiophene → 6-Benzyloxy-2-dimethylaminobenzo[b]thiophen-3-yl 3-Methoxy-4-[(1-pyrrolidinyl)methyl]phenyl Ketone

HRID 1387125ノート

反応式

HRID 1387125 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6]([O:8]C)=O.[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[CH:34]=[C:33]([N:35]([CH3:37])[CH3:36])[S:32][C:31]=2[CH:38]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]([C:34]2[C:30]3[CH:29]=[CH:28][C:27]([O:26][CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:38][C:31]=3[S:32][C:33]=2[N:35]([CH3:37])[CH3:36])=[O:8])[CH:10]=[CH:11][C:12]=1[CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1

参加物

3

反応物 2

HCID 106129946-Benzyloxy-2-dimethylaminobenzo[b]thiopheneHCID 10824510Methyl 3-methoxy-4-(pyrrolidin-1-ylmethyl)benzoate

生成物 1

HCID 106730126-Benzyloxy-2-dimethylaminobenzo[b]thiophen-3-yl 3-Methoxy-4-[(1-pyrrolidinyl)methyl]phenyl Ketone収率 80%

実験手順

Following essentially the procedure of Example 208, Part B, the title compound was prepared from methyl 3-methoxy-4-[(1-pyrrolidinyl)methyl]benzoate (Example 139, Part B) and 6-benzyloxy-2-dimethylaminobenzo[b]thiophene in 80% yield.

出典と根拠

ORDレコード
ord-e3a05f8cc16c4515bce440d86f5c520c
出典データセット
uspto-grants-2001_07
特許番号
US06265575B1

反応ノート

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